Ontology highlight
ABSTRACT:
SUBMITTER: McRae EKS
PROVIDER: S-EPMC5700478 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
McRae Ewan K S EKS Booy Evan P EP Padilla-Meier Gay Pauline GP McKenna Sean A SA
Journal of nucleic acids 20171109
Guanine quadruplexes (G4s) are four-stranded secondary structures of nucleic acids which are stabilized by noncanonical hydrogen bonding systems between the nitrogenous bases as well as extensive base stacking, or pi-pi, interactions. Formation of these structures in either genomic DNA or cellular RNA has the potential to affect cell biology in many facets including telomere maintenance, transcription, alternate splicing, and translation. Consequently, G4s have become therapeutic targets and sev ...[more]