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Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study.


ABSTRACT: To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).A prospective cohort study.University medical centre.Fifty-one adult patients who had undergone CRS-HIPEC and twenty control participants.The inflammatory marker levels in plasma and cognitive function were measured.Twenty (39.2%, 20/51) patients developed POCD at 1?w after CRS-HIPEC. The patients with POCD had higher serum interleukin 1? (IL-1?), serum amyloid A (SAA), S100 calcium-binding protein ? (S-100?), and high mobility group box-1 protein (HMGB-1) levels at 1 and 24?h postoperatively than patients without POCD. There was an association between POCD and the maximum IL-1? and S-100? concentrations in serum, which remained following adjustment for age and FBS.In this pilot study, perioperative inflammatory marker levels increase significantly after CRS-HIPEC in adult patients, and such elevations are associated with the development of short-term cognitive dysfunction after this complex surgery. These results suggested the need for a larger RCT to replicate and confirm these findings.

SUBMITTER: Yu H 

PROVIDER: S-EPMC5700480 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study.

Yu Hui H   Dong Rui R   Lu Yayuan Y   Yang Xi X   Chen Chang C   Zhang Zongze Z   Peng Mian M  

Mediators of inflammation 20171109


<h4>Objectives</h4>To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).<h4>Design</h4>A prospective cohort study.<h4>Setting</h4>University medical centre.<h4>Participants</h4>Fifty-one adult patients who had undergone CRS-HIPEC and twenty control participants.<h4>Measurements</h4>The inflammatory marker levels in plasma and cognitiv  ...[more]

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