PBxplore: a tool to analyze local protein structure and deformability with Protein Blocks.
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ABSTRACT:
SUBMITTER: Barnoud J
PROVIDER: S-EPMC5700758 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
PBxplore: a tool to analyze local protein structure and deformability with Protein Blocks.
Barnoud Jonathan J Santuz Hubert H Craveur Pierrick P Joseph Agnel Praveen AP Jallu Vincent V de Brevern Alexandre G AG Poulain Pierre P
PeerJ 20171120
This paper describes the development and application of a suite of tools, called PBxplore, to analyze the dynamics and deformability of protein structures using Protein Blocks (PBs). Proteins are highly dynamic macromolecules, and a classical way to analyze their inherent flexibility is to perform molecular dynamics simulations. The advantage of using small structural prototypes such as PBs is to give a good approximation of the local structure of the protein backbone. More importantly, by reduc ...[more]
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