A simple procedure for estimating pseudo risk ratios from exposure to non-carcinogenic chemical mixtures.

ABSTRACT: Non-cancer risk assessment traditionally assumes a threshold of effect, below which there is a negligible risk of an adverse effect. The Agency for Toxic Substances and Disease Registry derives health-based guidance values known as Minimal Risk Levels (MRLs) as estimates of the toxicity threshold for non-carcinogens. Although the definition of an MRL, as well as EPA reference dose values (RfD and RfC), is a level that corresponds to "negligible risk," they represent daily exposure doses or concentrations, not risks. We present a new approach to calculate the risk at exposure to specific doses for chemical mixtures, the assumption in this approach is to assign de minimis risk at the MRL. The assigned risk enables the estimation of parameters in an exponential model, providing a complete dos

SUBMITTER: Scinicariello F 

PROVIDER: S-EPMC5700810 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature