Ontology highlight
ABSTRACT:
SUBMITTER: Srikhanta YN
PROVIDER: S-EPMC5700931 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Srikhanta Yogitha N YN Gorrell Rebecca J RJ Power Peter M PM Tsyganov Kirill K Boitano Matthew M Clark Tyson A TA Korlach Jonas J Hartland Elizabeth L EL Jennings Michael P MP Kwok Terry T
Scientific reports 20171123 1
The Helicobacter pylori phase variable gene modH, typified by gene HP1522 in strain 26695, encodes a N<sup>6</sup>-adenosine type III DNA methyltransferase. Our previous studies identified multiple strain-specific modH variants (modH1 - modH19) and showed that phase variation of modH5 in H. pylori P12 influenced expression of motility-associated genes and outer membrane protein gene hopG. However, the ModH5 DNA recognition motif and the mechanism by which ModH5 controls gene expression were unkn ...[more]