A structurally distinct TGF-? mimic from an intestinal helminth parasite potently induces regulatory T cells.
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ABSTRACT:
SUBMITTER: Johnston CJC
PROVIDER: S-EPMC5701006 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.
Johnston Chris J C CJC Smyth Danielle J DJ Kodali Ravindra B RB White Madeleine P J MPJ Harcus Yvonne Y Filbey Kara J KJ Hewitson James P JP Hinck Cynthia S CS Ivens Alasdair A Kemter Andrea M AM Kildemoes Anna O AO Le Bihan Thierry T Soares Dinesh C DC Anderton Stephen M SM Brenn Thomas T Wigmore Stephen J SJ Woodcock Hannah V HV Chambers Rachel C RC Hinck Andrew P AP McSorley Henry J HJ Maizels Rick M RM
Nature communications 20171123 1
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF- ...[more]
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2021-04-29 | GSE164548 | GEO