Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.
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ABSTRACT:
SUBMITTER: Simeoli R
PROVIDER: S-EPMC5701122 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.
Simeoli Raffaele R Montague Karli K Jones Hefin R HR Castaldi Laura L Chambers David D Kelleher Jayne H JH Vacca Valentina V Pitcher Thomas T Grist John J Al-Ahdal Hadil H Wong Liang-Fong LF Perretti Mauro M Lai Johnathan J Mouritzen Peter P Heppenstall Paul P Malcangio Marzia M
Nature communications 20171124 1
Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies release extracellular vesicles, including exosomes containing miRs, upon activity. We demonstrate that miR-21-5p is released in the exosomal fraction of cultured DRG following capsaicin activation of TRPV1 receptors. Pure sensory neuron-derived exosomes released by capsaicin are readily phagocytosed by macrophages in which an ...[more]
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