The clinical significance of plasma clusterin and Aβ in the longitudinal follow-up of patients with Alzheimer's disease.

ABSTRACT:

Background

Clusterin and beta-amyloid (Aβ) are involved in the pathogenesis of Alzheimer's disease (AD). The clinical significance of plasma clusterin and Aβ in AD progression remains controversial.

Methods

We recruited 322 patients with AD and 88 controls between August 2012 and June 2013. All participants were evaluated at baseline with a clinical assessment, Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) scales. Patients with AD were evaluated annually with the MMSE and Neuropsychiatric Inventory (NPI) scale during the 2-year follow-up period. The levels of plasma clusterin, Aβ1-40, and Aβ1-42 at baseline were analyzed to study the longitudinal changes in the patient scores on the MMSE and NPI during the follow-up period.

Results

Patients

SUBMITTER: Hsu JL 

PROVIDER: S-EPMC5701424 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature