Ontology highlight
ABSTRACT:
SUBMITTER: Wong RWJ
PROVIDER: S-EPMC5701524 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Wong Regina Wan Ju RWJ Ngoc Phuong Cao Thi PCT Leong Wei Zhong WZ Yam Alice Wei Yee AWY Zhang Tinghu T Asamitsu Kaori K Iida Shinsuke S Okamoto Takashi T Ueda Ryuzo R Gray Nathanael S NS Ishida Takashi T Sanda Takaomi T
Blood 20171004 21
A number of studies have recently demonstrated that super-enhancers, which are large cluster of enhancers typically marked by a high level of acetylation of histone H3 lysine 27 and mediator bindings, are frequently associated with genes that control and define cell identity during normal development. Super-enhancers are also often enriched at cancer genes in various malignancies. The identification of such enhancers would pinpoint critical factors that directly contribute to pathogenesis. In th ...[more]