Ontology highlight
ABSTRACT:
SUBMITTER: Xiao E
PROVIDER: S-EPMC5701758 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Xiao E E Mattos Marcelo M Vieira Gustavo Henrique Apolinário GHA Chen Shanshan S Corrêa Jôice Dias JD Wu Yingying Y Albiero Mayra Laino ML Bittinger Kyle K Graves Dana T DT
Cell host & microbe 20170701 1
Diabetes is a risk factor for periodontitis, an inflammatory bone disorder and the greatest cause of tooth loss in adults. Diabetes has a significant impact on the gut microbiota; however, studies in the oral cavity have been inconclusive. By 16S rRNA sequencing, we show here that diabetes causes a shift in oral bacterial composition and, by transfer to germ-free mice, that the oral microbiota of diabetic mice is more pathogenic. Furthermore, treatment with IL-17 antibody decreases the pathogeni ...[more]