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ABSTRACT: Introduction
To address the lack of genomic data from Hispanic/Latino (H/L) patients with lung cancer, the Latino Lung Cancer Registry was established to collect patient data and biospecimens from H/L patients.Methods
This retrospective observational study examined lung cancer tumor samples from 163 H/L patients, and tumor-derived DNA was subjected to targeted-exome sequencing (>1000 genes, including EGFR, KRAS, serine/threonine kinase 11 gene [STK11], and tumor protein p53 gene [TP53]) and ancestry analysis. Mutation frequencies in this H/L cohort were compared with those in a similar cohort of non-Hispanic white (NHW) patients and correlated with ancestry, sex, smoking status, and tumor histologic type.Results
Of the adenocarcinomas in the H/L cohort (n = 120), 31% had EGFR mutations, versus 17% in the NHW control group (p < 0.001). KRAS (20% versus 38% [p = 0.002]) and STK11 (8% versus 16% [p = 0.065]) mutations occurred at lower frequency, and mutations in TP53 occurred at similar frequency (46% versus 40% [p = 0.355]) in H/L and NHW patients, respectively. Within the Hispanic cohort, ancestry influenced the rate of TP53 mutations (p = 0.009) and may have influenced the rate of EGFR, KRAS, and STK11 mutations.Conclusions
Driver mutations in H/L patients with lung adenocarcinoma differ in frequency from those in NHW patients associated with their indigenous American ancestry. The spectrum of driver mutations needs to be further assessed in the H/L population.
SUBMITTER: Gimbrone NT
PROVIDER: S-EPMC5701827 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Gimbrone Nicholas T NT Sarcar Bhaswati B Gordian Edna R ER Rivera Jason I JI Lopez Christian C Yoder Sean J SJ Teer Jamie K JK Welsh Eric A EA Chiappori Alberto A AA Schabath Matthew B MB Reuther Gary W GW Dutil Julie J Garcia Miosotis M Ventosilla-Villanueva Ronald R Vera-Valdivia Luis L Yabar-Berrocal Alejandro A Motta-Guerrero Rodrigo R Santiago-Cardona Pedro G PG Muñoz-Antonia Teresita T Cress W Douglas WD
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20170911 12
<h4>Introduction</h4>To address the lack of genomic data from Hispanic/Latino (H/L) patients with lung cancer, the Latino Lung Cancer Registry was established to collect patient data and biospecimens from H/L patients.<h4>Methods</h4>This retrospective observational study examined lung cancer tumor samples from 163 H/L patients, and tumor-derived DNA was subjected to targeted-exome sequencing (>1000 genes, including EGFR, KRAS, serine/threonine kinase 11 gene [STK11], and tumor protein p53 gene ...[more]