Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury.

ABSTRACT:

Background

The diagnosis of acute kidney injury (AKI), which is currently defined as an increase in serum creatinine (Scr) concentration, provides little information on the condition's actual cause. To improve phenotyping of AKI, many urinary biomarkers of tubular injury are being investigated. Because AKI cases are not frequently biopsied, the diagnostic accuracy of concentrations of Scr and urinary biomarkers for histologic acute tubular injury is unknown.

Study design

Cross-sectional analysis from multicenter prospective cohort.

Settings & participants

Hospitalized deceased kidney donors on whom kidney biopsies were performed at the time of organ procurement for histologic evaluation.

Predictors

(1) AKI diagnosed by change in Scr concentration during donor h

SUBMITTER: Moledina DG 

PROVIDER: S-EPMC5701867 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature