Over-expression of miR-146b and its regulatory role in intestinal epithelial cell viability, proliferation, and apoptosis in piglets.
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ABSTRACT:
SUBMITTER: Tao X
PROVIDER: S-EPMC5702241 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Over-expression of miR-146b and its regulatory role in intestinal epithelial cell viability, proliferation, and apoptosis in piglets.
Tao Xin X Liu Shujie S Men Xiaoming X Xu Ziwei Z
Biology direct 20171125 1
<h4>Background</h4>Weaning stress affects the small intestine of piglets. MiR-146b is differentially expressed in suckling and weaned piglets. In this study, we evaluated the effects of miR-146b on cell viability, proliferation, and apoptosis in IPEC-J2 cells.<h4>Results</h4>Transfection with miR-146b mimics successfully increased miR-146b levels by 1000× (P < 0.001). The over-expression of miR-146b significantly promoted the apoptosis (P < 0.01) of IPEC-J2 cells, with no significant effects on ...[more]
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