MRI evaluation of regional and longitudinal changes in Z-spectra of injured spinal cord of monkeys.

ABSTRACT:

Purpose

In principle, MR methods that exploit magnetization transfer (MT) may be used to quantify changes in the molecular composition of tissues after injury. The ability to track such changes in injured spinal cord may allow more precise assessment of the state of neural tissues.

Methods

Z-Spectra were obtained from the cervical spinal cord before and after a unilateral dorsal column lesion in monkeys at 9.4T. The amplitudes of chemical exchange saturation transfer (CEST) and nuclear Overhauser enhancement (NOE) effects from multiple proton pools, along with nonspecific semisolid MT effects from immobile macromolecules, were quantified using a five-peak Lorenzian fitting of each Z-spectrum.

Results

Abnormal tissues/cysts that formed around lesion sites exhibited rel

SUBMITTER: Wang F 

PROVIDER: S-EPMC5702279 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature