Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications.
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ABSTRACT:
SUBMITTER: Valdes-Rives SA
PROVIDER: S-EPMC5702396 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications.
Valdés-Rives Silvia Anahi SA Casique-Aguirre Diana D Germán-Castelán Liliana L Velasco-Velázquez Marco A MA González-Arenas Aliesha A
BioMed research international 20171112
Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets. ...[more]
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