Immunoregulatory functions of VISTA.
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ABSTRACT:
SUBMITTER: Nowak EC
PROVIDER: S-EPMC5702497 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Immunoregulatory functions of VISTA.
Nowak Elizabeth C EC Lines J Louise JL Varn Frederick S FS Deng Jie J Sarde Aurelien A Mabaera Rodwell R Kuta Anna A Le Mercier Isabelle I Cheng Chao C Noelle Randolph J RJ
Immunological reviews 20170301 1
Utilization of negative checkpoint regulators (NCRs) for cancer immunotherapy has garnered significant interest with the completion of clinical trials demonstrating efficacy. While the results of monotherapy treatments are compelling, there is increasing emphasis on combination treatments in an effort to increase response rates to treatment. One of the most recently discovered NCRs is VISTA (V-domain Ig-containing Suppressor of T cell Activation). In this review, we describe the functions of thi ...[more]
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