Ontology highlight
ABSTRACT:
SUBMITTER: Modi BP
PROVIDER: S-EPMC5702565 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Modi Bhavi P BP Teves Maria E ME Pearson Laurel N LN Parikh Hardik I HI Haymond-Thornburg Hannah H Tucker John L JL Chaemsaithong Piya P Chaemsaithong Piya P Gomez-Lopez Nardhy N York Timothy P TP Romero Roberto R Strauss Jerome F JF
Molecular genetics & genomic medicine 20170823 6
<h4>Background</h4>Twin studies have revealed a significant contribution of the fetal genome to risk of preterm birth. Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm delivery. Infection and inflammation of the fetal membranes is commonly found associated with PPROM.<h4>Methods</h4>We carried out whole exome sequencing (WES) of genomic DNA from neonates born of African-American mothers whose pregnancies were complicated by PPROM (76) or were normal ter ...[more]