Ontology highlight
ABSTRACT:
SUBMITTER: Zhang T
PROVIDER: S-EPMC5702604 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zhang Tingxin T Chi Shaopeng S Jiang Fan F Zhao Qiancheng Q Xiao Bailong B
Nature communications 20171127 1
Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like homo-trimer comprising a central pore-module and three propeller-structures that might serve as mechanotransduction-modules. However, the mechanogating and regulation of Piezo channels remain unclear. Here we identify the sarcoplasmic /endoplasmic-reticulum Ca<sup>2+</sup> ATPase (SERCA), including the widel ...[more]