Ontology highlight
ABSTRACT:
SUBMITTER: Clarkson J
PROVIDER: S-EPMC5703322 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20171106 47
The pulsatile release of luteinizing hormone (LH) is critical for mammalian fertility. However, despite several decades of investigation, the identity of the neuronal network generating pulsatile reproductive hormone secretion remains unproven. We use here a variety of optogenetic approaches in freely behaving mice to evaluate the role of the arcuate nucleus kisspeptin (ARN<sup>KISS</sup>) neurons in LH pulse generation. Using GCaMP6 fiber photometry, we find that the ARN<sup>KISS</sup> neuron p ...[more]