Ontology highlight
ABSTRACT:
SUBMITTER: Lee JY
PROVIDER: S-EPMC5704066 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Lee Jae Young JY Kim Min Joung MJ Deliyanti Devy D Azari Michael F MF Rossello Fernando F Costin Adam A Ramm Georg G Stanley Edouard G EG Elefanty Andrew G AG Wilkinson-Berka Jennifer L JL Petratos Steven S
EBioMedicine 20171019
Cell membrane thyroid hormone (TH) transport can be facilitated by the monocarboxylate transporter 8 (MCT8), encoded by the solute carrier family 16 member 2 (SLC16A2) gene. Human mutations of the gene, SLC16A2, result in the X-linked-inherited psychomotor retardation and hypomyelination disorder, Allan-Herndon-Dudley syndrome (AHDS). We posited that abrogating MCT8-dependent TH transport limits oligodendrogenesis and myelination. We show that human oligodendrocytes (OL), derived from the NKX2.1 ...[more]