Ontology highlight
ABSTRACT:
SUBMITTER: De Martino M
PROVIDER: S-EPMC5704243 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
De Martino Marco M Palma Giuseppe G Azzariti Amalia A Arra Claudio C Fusco Alfredo A Esposito Francesco F
Genes 20171117 11
Several studies have established that pseudogene mRNAs can work as competing endogenous RNAs and, when deregulated, play a key role in the onset of human neoplasias. Recently, we have isolated two <i>HMGA1</i> pseudogenes, <i>HMGA1P6</i> and <i>HMGA1P7</i>. These pseudogenes have a critical role in cancer progression, acting as micro RNA (miRNA) sponges for <i>HMGA1</i> and other cancer-related genes. <i>HMGA1</i> pseudogenes were found overexpressed in several human carcinomas, and their expres ...[more]