Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis.

ABSTRACT: Previous studies have associated the Interleukin-1 (IL-1) gene clusters polymorphisms with the risk of primary open-angle glaucoma (POAG). However, the results were not consistent. Here, we performed a meta-analysis to evaluate the role of IL-1 gene clusters polymorphisms in POAG susceptibility.PubMed, EMBASE and Cochrane Library (up to July 15, 2017) were searched by two independent investigators. All case-control studies investigating the association between single-nucleotide polymorphisms (SNPs) of IL-1 gene clusters and POAG risk were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for quantifying the strength of association that has been involved in at least two studies.Five studies on IL-1? rs16944 (c. -511C?>?T) (1053 cases and 986 controls), 4 studies on IL-1? rs1800587 (c. -889C?>?T) (822 cases and 714 controls), and 4 studies on IL-1? rs1143634 (c. +3953C?>?T) (798 cases and 730 controls) were included. The results suggest that all three SNPs were not associated with POAG risk. Stratification analyses indicated that the rs1143634 has a suggestive associated with high tension glaucoma (HTG) under dominant (P?=?0.03), heterozygote (P?=?0.04) and allelic models (P?=?0.02), however, the weak association was nullified after Bonferroni adjustments for multiple tests.Based on current meta-analysis, we indicated that there is lack of association between the three SNPs of IL-1 and POAG. However, this conclusion should be interpreted with caution and further well designed studies with large sample-size are required to validate the conclusion as low statistical powers.

SUBMITTER: Li J 

PROVIDER: S-EPMC5704439 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature