Are Perinatal Events Risk Factors for Childhood Thyroid Autoimmunity?

ABSTRACT:

Background

Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse.

Objectives

The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study.

Methods

Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes. Information on perinatal events and family history of autoimmunity was gathered prospectively in questionnaires.

Results

Thyroid autoimmunity was found in 6.9% of the children (TPOAb 4.4%, TGAb 5.8%, both autoantibodies 3.3%) and

SUBMITTER: Jonsdottir B 

PROVIDER: S-EPMC5704722 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature