Ontology highlight
ABSTRACT:
SUBMITTER: Thomas A
PROVIDER: S-EPMC5705182 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Thomas Anish A Lee Jih-Hsiang JH Abdullaev Zied Z Park Kang-Seo KS Pineda Marbin M Saidkhodjaeva Lola L Miettinen Markku M Wang Yisong Y Pack Svetlana D SD Giaccone Giuseppe G
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20140401 4
<h4>Introduction</h4>There remains a significant therapeutic need for small-cell lung cancer (SCLC). We and others have reported high frequency of copy number gains in cytogenetic bands encoding fibroblast growth factor receptor 1 (FGFR1) in SCLC tumors and cell lines.<h4>Methods</h4>Thirteen SCLC cell lines and 68 SCLC patient tumor samples were studied for FGFR1 amplification. Growth inhibition assays were performed using PD173074, a pan-FGFR inhibitor to determine the correlation between FGFR ...[more]