Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC5705218 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zhang Haoran H Wang Li L Wong Elaine Yee Man EYM Tsang Sze Lan SL Xu Pin-Xian PX Lendahl Urban U Sham Mai Har MH
eLife 20171115
Craniofacial morphogenesis requires proper development of pharyngeal arches and epibranchial placodes. We show that the epibranchial placodes, in addition to giving rise to cranial sensory neurons, generate a novel lineage-related non-neuronal cell population for mouse pharyngeal arch development. Eya1 is essential for the development of epibranchial placodes and proximal pharyngeal arches. We identify an Eya1-Notch regulatory axis that specifies both the neuronal and non-neuronal commitment of ...[more]