Ontology highlight
ABSTRACT:
SUBMITTER: Zhou C
PROVIDER: S-EPMC5705222 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zhou Chan C Molinie Benoit B Daneshvar Kaveh K Pondick Joshua V JV Wang Jinkai J Van Wittenberghe Nicholas N Xing Yi Y Giallourakis Cosmas C CC Mullen Alan C AC
Cell reports 20170801 9
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most abundant internal modification of mRNAs and is implicated in all aspects of post-transcriptional RNA metabolism. However, little is known about m<sup>6</sup>A modifications to circular (circ) RNAs. We developed a computational pipeline (AutoCirc) that, together with depletion of ribosomal RNA and m<sup>6</sup>A immunoprecipitation, defined thousands of m<sup>6</sup>A circRNAs with cell-type-specific expression. The presence of m<sup>6</s ...[more]