Does Mineralocorticoid Receptor Antagonism Prevent Calcineurin Inhibitor-Induced Nephrotoxicity?
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ABSTRACT:
SUBMITTER: Mortensen LA
PROVIDER: S-EPMC5705552 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Does Mineralocorticoid Receptor Antagonism Prevent Calcineurin Inhibitor-Induced Nephrotoxicity?
Mortensen Line Aas LA Bistrup Claus C Thiesson Helle Charlotte HC
Frontiers in medicine 20171124
Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial fibrosis and tubular atrophy, which impairs long-term allograft survival. The mineralocorticoid hormone aldosterone induces fibrosis in numerous organs, including the kidney. Evidence from animal models suggests a beneficial effect of aldosterone antago ...[more]
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