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Association between antibodies against group B Streptococcus surface proteins and recto-vaginal colonisation during pregnancy.


ABSTRACT: Group B Streptococcus (GBS) recto-vaginal colonisation in pregnant women is the major risk factor for early-onset invasive GBS disease in their newborns. We aimed to determine the association between serum antibody levels against 11 GBS surface proteins and recto-vaginal acquisition of GBS colonisation during pregnancy. Sera collected from pregnant women at 20-25 weeks and ?37 weeks of gestation age were measured for IgG titres against GBS surface proteins using  a multiplex immunoassay. Women were evaluated for recto-vaginal colonisation every 4-5 weeks. We observed that the likelihood of becoming colonised with GBS during pregnancy was lower in women with IgG titres ?200?U/mL against gbs0233 (adjusted OR?=?0.47 [95% CI: 0.25-0.89], p?=?0.021) and ?85?U/mL for gbs1539 (adjusted OR?=?0.44 [95% CI: 0.24-0.82], p?=?0.01) when comparing between women who acquired GBS colonisation and those that remained free of GBS colonisation throughout pregnancy. IgG titres (U/mL) specific to BibA and Sip were higher in pregnant women colonised with GBS (380.19 and 223.87, respectively) compared to women with negative GBS cultures (234.42 and 186.21, respectively; p?

SUBMITTER: Dzanibe S 

PROVIDER: S-EPMC5705700 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Association between antibodies against group B Streptococcus surface proteins and recto-vaginal colonisation during pregnancy.

Dzanibe Sonwabile S   Kwatra Gaurav G   Adrian Peter V PV   Kimaro-Mlacha Sheila Z SZ   Cutland Clare L CL   Madhi Shabir A SA  

Scientific reports 20171128 1


Group B Streptococcus (GBS) recto-vaginal colonisation in pregnant women is the major risk factor for early-onset invasive GBS disease in their newborns. We aimed to determine the association between serum antibody levels against 11 GBS surface proteins and recto-vaginal acquisition of GBS colonisation during pregnancy. Sera collected from pregnant women at 20-25 weeks and ≥37 weeks of gestation age were measured for IgG titres against GBS surface proteins using  a multiplex immunoassay. Women w  ...[more]

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