Epigenetic modifiers in immunotherapy: a focus on checkpoint inhibitors.
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ABSTRACT:
SUBMITTER: Terranova-Barberio M
PROVIDER: S-EPMC5705793 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Epigenetic modifiers in immunotherapy: a focus on checkpoint inhibitors.
Terranova-Barberio Manuela M Thomas Scott S Munster Pamela N PN
Immunotherapy 20160601 6
Immune surveillance should be directed to suppress tumor development and progression, involving a balance of coinhibitory and costimulatory signals that amplify immune response without overwhelming the host. Immunotherapy confers durable clinical benefit in 'immunogenic tumors', whereas in other tumors the responses are modest. Thus, immune checkpoint inhibitors may need to be combined with strategies to boost immune response or increase the tumor immune profile. Epigenetic aberrations contribut ...[more]
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