Cucumarioside A?-2 Causes Macrophage Activation in Mouse Spleen.
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ABSTRACT:
SUBMITTER: Pislyagin EA
PROVIDER: S-EPMC5706031 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Cucumarioside A₂-2 Causes Macrophage Activation in Mouse Spleen.
Pislyagin Evgeny A EA Manzhulo Igor V IV Gorpenchenko Tatiana Y TY Dmitrenok Pavel S PS Avilov Sergey A SA Silchenko Alexandra S AS Wang Yun-Ming YM Aminin Dmitry L DL
Marine drugs 20171101 11
The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber <i>Cucumaria japonica</i>, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (<i>i.p.</i>) glycoside administration leads to increased spleen macrophage activating markers iba-1, IL-1β, iNOs, ROS and NO formation, with additional change of macrophage phenotype to M1. The mass spectrometry profiles of peptide/protein were o ...[more]
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