A Red Carpet for Iron Metabolism.
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ABSTRACT:
SUBMITTER: Muckenthaler MU
PROVIDER: S-EPMC5706455 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
A Red Carpet for Iron Metabolism.
Muckenthaler Martina U MU Rivella Stefano S Hentze Matthias W MW Galy Bruno B
Cell 20170101 3
200 billion red blood cells (RBCs) are produced every day, requiring more than 2 × 10<sup>15</sup> iron atoms every second to maintain adequate erythropoiesis. These numbers translate into 20 mL of blood being produced each day, containing 6 g of hemoglobin and 20 mg of iron. These impressive numbers illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss recent progress in understanding the systemic and cellular mechanisms that un ...[more]
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