PTTG3P promotes gastric tumour cell proliferation and invasion and is an indicator of poor prognosis.
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ABSTRACT:
SUBMITTER: Weng W
PROVIDER: S-EPMC5706523 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
PTTG3P promotes gastric tumour cell proliferation and invasion and is an indicator of poor prognosis.
Weng Weiwei W Ni Shujuan S Wang Yiqin Y Xu Midie M Zhang Qiongyan Q Yang Yusi Y Wu Yong Y Xu Qinghua Q Qi Peng P Tan Cong C Huang Dan D Wei Ping P Huang Zhaohui Z Ma Yuqing Y Zhang Wei W Sheng Weiqi W Du Xiang X
Journal of cellular and molecular medicine 20170619 12
Pseudogenes play a crucial role in cancer progression. However, the role of pituitary tumour-transforming 3, pseudogene (PTTG3P) in gastric cancer (GC) remains unknown. Here, we showed that PTTG3P expression was abnormally up-regulated in GC tissues compared with that in normal tissues both in our 198 cases of clinical samples and the cohort from The Cancer Genome Atlas (TCGA) database. High PTTG3P expression was correlated with increased tumour size and enhanced tumour invasiveness and served a ...[more]
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