Ontology highlight
ABSTRACT:
SUBMITTER: Cabo M
PROVIDER: S-EPMC5706611 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Oncoimmunology 20170830 12
The goal of cancer immunotherapy is to establish new or boost pre-existing anticancer immune responses that eradicate malignant cells while generating immunological memory to prevent disease relapse. Over the past few years, immunomodulatory monoclonal antibodies (mAbs) that block co-inhibitory receptors on immune effectors cells - such as cytotoxic T lymphocyte-associated protein 4 (CTLA4), programmed cell death 1 (PDCD1, best known as PD-1) - or their ligands - such as CD274 (best known as PD- ...[more]