Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.
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ABSTRACT:
SUBMITTER: Mike LA
PROVIDER: S-EPMC5706644 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.
Mike Laura A LA Tripathi Ashootosh A Blankenship Connor M CM Saluk Alyssa A Schultz Pamela J PJ Tamayo-Castillo Giselle G Sherman David H DH Mobley Harry L T HLT
Chemical communications (Cambridge, England) 20171101 95
High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections. ...[more]
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