Ontology highlight
ABSTRACT:
SUBMITTER: Shahin F
PROVIDER: S-EPMC5706888 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Shahin Farzana F Raza Sohail S Yang Kui K Hu Changmin C Chen Yingyu Y Chen Huanchun H Guo Aizhen A
Oncotarget 20171010 55
<i>Bovine herpesvirus 1</i> (BoHV-1) <i>UL21</i> is a tegument protein thought to be indispensable for efficient viral growth but its precise function in BoHV-1 is currently unknown. To determine the function of <i>UL21</i> in BoHV-1 replication, we constructed a mutant virus bearing a <i>UL21</i> deletion (vBoHV-1-∆UL21) and its revertant virus, vBoHV-1-∆UL21R, in which the <i>UL21</i> gene was restored using a bacterial artificial chromosome system. The replication of vBoHV-1-∆UL21 was 1,000-f ...[more]