Ontology highlight
ABSTRACT:
SUBMITTER: Arnould S
PROVIDER: S-EPMC5707016 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Arnould Stéphanie S Rodier Geneviève G Matar Gisèle G Vincent Charles C Pirot Nelly N Delorme Yoann Y Berthet Charlène C Buscail Yoan Y Noël Jean Yohan JY Lachambre Simon S Jarlier Marta M Bernex Florence F Delpech Hélène H Vidalain Pierre Olivier PO Janin Yves L YL Theillet Charles C Sardet Claude C
Oncotarget 20170712 56
Reduction in nucleotide pools through the inhibition of mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) has been demonstrated to effectively reduce cancer cell proliferation and tumour growth. The current study sought to investigate whether this antiproliferative effect could be enhanced by combining Chk1 kinase inhibition. The pharmacological activity of DHODH inhibitor teriflunomide was more selective towards transformed mouse embryonic fibroblasts than their primary or immortalised ...[more]