Ontology highlight
ABSTRACT:
SUBMITTER: Ando T
PROVIDER: S-EPMC5707161 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Ando Tomoaki T Kashiwakura Jun-Ichi JI Itoh-Nagato Naoka N Yamashita Hirotaka H Baba Minato M Kawakami Yu Y Tsai Shih Han SH Inagaki Naoki N Takeda Kiyoshi K Iwata Tsutomu T Shimojo Naoki N Fujisawa Takao T Nagao Mizuho M Matsumoto Kenji K Kawakami Yuko Y Kawakami Toshiaki T
The Journal of clinical investigation 20171113 12
Food allergy occurs due to IgE- and mast cell-dependent intestinal inflammation. Previously, we showed that histamine-releasing factor (HRF), a multifunctional protein secreted during allergy, interacts with a subset of IgE molecules and that the HRF dimer activates mast cells in an HRF-reactive IgE-dependent manner. In this study, we investigated whether HRF plays any role in food allergy. Specifically, we determined that prophylactic and therapeutic administration of HRF inhibitors that block ...[more]