Ontology highlight
ABSTRACT:
SUBMITTER: Tian D
PROVIDER: S-EPMC5707411 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Tian Daiyin D Battles Michael B MB Moin Syed M SM Chen Man M Modjarrad Kayvon K Kumar Azad A Kanekiyo Masaru M Graepel Kevin W KW Taher Noor M NM Hotard Anne L AL Moore Martin L ML Zhao Min M Zheng Zi-Zheng ZZ Xia Ning-Shao NS McLellan Jason S JS Graham Barney S BS
Nature communications 20171130 1
A licensed vaccine for respiratory syncytial virus (RSV) is unavailable, and passive prophylaxis with the antibody palivizumab is restricted to high-risk infants. Recently isolated antibodies 5C4 and D25 are substantially more potent than palivizumab, and a derivative of D25 is in clinical trials. Here we show that unlike D25, 5C4 preferentially neutralizes subtype A viruses. The crystal structure of 5C4 bound to the RSV fusion (F) protein reveals that the overall binding mode of 5C4 is similar ...[more]