Hyperpolarization of amino acid derivatives in water for biological applications.
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ABSTRACT:
SUBMITTER: Gloggler S
PROVIDER: S-EPMC5707458 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Hyperpolarization of amino acid derivatives in water for biological applications.
Glöggler S S Wagner S S Bouchard L-S LS
Chemical science 20150526 7
We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% <sup>13</sup>C-polarization), meeting required levels for <i>in vivo</i> detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity. ...[more]
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