Ontology highlight
ABSTRACT:
SUBMITTER: Peng Q
PROVIDER: S-EPMC5707869 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Peng Qiaohua Q Qin Jiale J Zhang Yanan Y Cheng Xiaodong X Wang Xinyu X Lu Weiguo W Xie Xing X Zhang Songfa S
Journal of experimental & clinical cancer research : CR 20171129 1
<h4>Background</h4>Cancer stem cells (CSCs) are regarded as the main cell type responsible for the initiation, metastasis, drug resistance, and recurrence of cancer. But the mechanism by which cancer stem cells maintain their stemness remains unclear.<h4>Methods and results</h4>In the present study, ovarian cancer stem cells (OCSCs) were revealed to have an enhanced autophagic flux. Furthermore, their chemoresistance and ability to self-renewal in vitro were decreased when autophagy was inhibite ...[more]