Early clinical outcomes as a function of use of newer oral P2Y₁₂ inhibitors versus clopidogrel in the EUROMAX trial.

ABSTRACT:

Objective

To ascertain whether different oral P2Y₁₂ inhibitors might affect rates of acute stent thrombosis and 30-day outcomes after primary percutaneous coronary intervention (pPCI).

Methods

The European Ambulance Acute Coronary Syndrome Angiography (EUROMAX) randomised trial compared prehospital bivalirudin with heparin with optional glycoprotein IIb/IIIa inhibitor treatment in patients with ST-segment elevation myocardial infarction triaged to pPCI. Choice of P2Y₁₂ inhibitor was at the investigator's discretion. In a prespecified analysis, we compared event rates with clopidogrel and newer oral P2Y₁₂ inhibitors (prasugrel, ticagrelor). Rates of the primary outcome (acute stent thrombosis) were examined as a function of the P2Y₁₂

SUBMITTER: Huber K 

PROVIDER: S-EPMC5708315 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature