Local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders.
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ABSTRACT:
SUBMITTER: Keown CL
PROVIDER: S-EPMC5708538 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
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Local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders.
Keown Christopher Lee CL Shih Patricia P Nair Aarti A Peterson Nick N Mulvey Mark Edward ME Müller Ralph-Axel RA
Cell reports 20131107 3
Although growing evidence indicates atypical long-distance connectivity in autism spectrum disorder (ASD), much less is known about local connectivity, despite conjectures that local overconnectivity may be causally involved in the disorder. Using functional connectivity MRI and graph theory, we found that local functional connectivity was atypically increased in adolescents with ASD in temporo-occipital regions bilaterally. Posterior overconnectivity was found to be associated with higher ASD s ...[more]
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