Ontology highlight
ABSTRACT:
SUBMITTER: D'Amato AR
PROVIDER: S-EPMC5708548 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
D'Amato Anthony R AR Schaub Nicholas J NJ Cardenas Jesus M JM Fiumara Andrew S AS Troiano Paul M PM Fischetti Andrea A Gilbert Ryan J RJ
Polymer 20170703
A major challenge in developing drug-releasing electrospun nanofibers is obtaining long-term drug release over many weeks with no burst release of drug. Here, we present new methods capable of prolonging the diffusive release of small molecule drugs from electrospun poly-L-lactic acid (PLLA) nanofibers. The methods focus on removal of retained electrospinning solvent through fiber heating, maintaining fibers in a laboratory setting, or a combination of these methods. These post-fabrication metho ...[more]