Ontology highlight
ABSTRACT:
SUBMITTER: Fontes-Garfias CR
PROVIDER: S-EPMC5708593 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Fontes-Garfias Camila R CR Shan Chao C Luo Huanle H Muruato Antonio E AE Medeiros Daniele B A DBA Mays Elizabeth E Xie Xuping X Zou Jing J Roundy Christopher M CM Wakamiya Maki M Rossi Shannan L SL Wang Tian T Weaver Scott C SC Shi Pei-Yong PY
Cell reports 20171001 5
Zika virus (ZIKV) infection causes devastating congenital abnormities and Guillain-Barré syndrome. The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. Like other flaviviruses, the ZIKV E protein is glycosylated at amino acid N154. To study the function of E glycosylation, we generated a recombinant N154Q ZIKV that lacks the E glycosylation and analyzed the mutant virus in mammalian and mosquito hosts. In mouse models, the mutant ...[more]