Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis.

ABSTRACT: While dietary folate deficiency is associated with increased risk for birth defects and other diseases, evidence suggests that supplementation with folic acid can contribute to predisposition to some diseases, including immune dysfunction and cancer. Herein, we show that diets supplemented with folic acid both below and above the recommended levels led to significantly altered metabolism in multiple tissues in mice. Surprisingly, both low and excessive dietary folate induced similar metabolic changes, which were particularly evident for nucleotide biosynthetic pathways in B-progenitor cells. Diet-induced metabolic changes in these cells partially phenocopied those observed in mice treated with anti-folate drugs, suggesting that both deficiency and excessive levels of dietary folic acid com

SUBMITTER: Henry CJ 

PROVIDER: S-EPMC5709097 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature