Ontology highlight
ABSTRACT: Purpose
To develop a spectral-spatial (SPSP) excitation RF pulse for simultaneous water and lipid suppression in proton (1H) magnetic resonance spectroscopic imaging (MRSI) of body extremities.Methods
An SPSP excitation pulse is designed to excite Creatine (Cr) and Choline (Cho) metabolite signals while suppressing the overwhelming water and lipid signals. The SPSP pulse is designed using a recently proposed multidimensional Shinnar-Le Roux (SLR) RF pulse design method. A minimum-phase spectral selectivity profile is used to minimize signal loss from T2⁎ decay.Results
The performance of the SPSP pulse is evaluated via Bloch equation simulations and phantom experiments. The feasibility of the proposed method is demonstrated using three-dimensional, short repetition-time, free induction decay-based 1H-MRSI in the thigh muscle at 3T.Conclusion
The proposed SPSP excitation pulse is useful for simultaneous water and lipid suppression. The proposed method enables new applications of high-resolution 1H-MRSI in body extremities.
SUBMITTER: Han PK
PROVIDER: S-EPMC5709164 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Han Paul Kyu PK Ma Chao C Deng Kexin K Hu Shuang S Jee Kyung-Wook KW Ying Kui K Chen Yen-Lin YL El Fakhri Georges G
Magnetic resonance imaging 20170914
<h4>Purpose</h4>To develop a spectral-spatial (SPSP) excitation RF pulse for simultaneous water and lipid suppression in proton (<sup>1</sup>H) magnetic resonance spectroscopic imaging (MRSI) of body extremities.<h4>Methods</h4>An SPSP excitation pulse is designed to excite Creatine (Cr) and Choline (Cho) metabolite signals while suppressing the overwhelming water and lipid signals. The SPSP pulse is designed using a recently proposed multidimensional Shinnar-Le Roux (SLR) RF pulse design method ...[more]