Ontology highlight
ABSTRACT:
SUBMITTER: Lu P
PROVIDER: S-EPMC5709369 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Lu Panpan P Shen Yinzhong Y Yang He H Wang Yanan Y Jiang Zhengtao Z Yang Xinyi X Zhong Yangcheng Y Pan Hanyu H Xu Jianqing J Lu Hongzhou H Zhu Huanzhang H
Scientific reports 20171130 1
Persistent latent reservoir in resting CD4+ T cells is a major obstacle in curing HIV-1 infection. Effective strategies for eradication of the HIV-1 reservoir are urgently needed. We report here for the first time that two BET inhibitors, RVX-208, which has entered phase II clinical trials for diverse cardiovascular disorders, and PFI-1, which has been widely studied in oncology, can reactivate HIV-1 from latency. RVX-208 and PFI-1 treatment alone or in combination with other latency reversing a ...[more]