Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread.
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ABSTRACT:
SUBMITTER: Okafo G
PROVIDER: S-EPMC5709493 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread.
Okafo George G Prevedel Lisa L Eugenin Eliseo E
Scientific reports 20171130 1
Cell-to-cell communication is essen for the development of multicellular systems and is coordinated by soluble factors, exosomes, gap junction (GJ) channels, and the recently described tunneling nanotubes (TNTs). We and others have demonstrated that TNT-like structures are mostly present during pathogenic conditions, including HIV infection. However, the nature, function, and communication properties of TNTs are still poorly understood. In this manuscript, we demonstrate that TNTs induced by HIV ...[more]
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