Ontology highlight
ABSTRACT:
SUBMITTER: Wei F
PROVIDER: S-EPMC5709498 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Wei Fulan F Yang Shuangyan S Guo Qingyuan Q Zhang Xin X Ren Dapeng D Lv Tao T Xu Xin X
Scientific reports 20171130 1
Human periodontal ligament stem cells (hPDLSCs) are mesenchymal stem cells (MSCs) derived from dental and craniofacial tissues that exhibit high potential for differentiation into osteoblasts. Recently, microRNAs (miRNAs) have been established to play important roles in MSC osteogenesis. In the current study, we report that miR-21 was down-regulated in osteogenically differentiated PDLSCs. Overexpression of miR-21 significantly inhibited osteogenesis of hPDLSC, whereas its inhibition demonstrate ...[more]