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The long-term safety of D-allulose administration in healthy dogs.

ABSTRACT: The safety and biological effects of a long-term dose of D-allulose were evaluated in healthy dogs. For 12 weeks, the dogs were administered D-allulose (0.2 g/kg) or placebo daily. Plasma total cholesterol concentrations in the D-allulose group were significantly lower than those in the control group at and after week 2 (P<0.05). D-Allulose administration did not cause clinical signs or changes in hematological and biochemical levels, except for lipids. D-Allulose administration also did not influence body weight. Plasma glucose and insulin concentrations in the glucose tolerance test, performed one day after the termination of D-allulose administration, were not different between groups, suggesting no cumulative effects of D-allulose on glucose metabolism in healthy dogs. In conclusion, long-term administration of D-allulose caused no harmful effects in dogs.

SUBMITTER: Nishii N

PROVIDER: S-EPMC5709552 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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The long-term safety of D-allulose administration in healthy dogs.

Nishii Naohito N Takashima Satoshi S Kobatake Yui Y Tokuda Masaaki M Kitagawa Hitoshi H

The Journal of veterinary medical science 20170917 11

The safety and biological effects of a long-term dose of D-allulose were evaluated in healthy dogs. For 12 weeks, the dogs were administered D-allulose (0.2 g/kg) or placebo daily. Plasma total cholesterol concentrations in the D-allulose group were significantly lower than those in the control group at and after week 2 (P<0.05). D-Allulose administration did not cause clinical signs or changes in hematological and biochemical levels, except for lipids. D-Allulose administration also did not inf ...[more]

PMID: 28924091

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